Where should I go in New York City?

I am going to NYC next month and will be there for a week with New Year's Eve right smack in the middle of that week. I've been to New York before so I've seen most of the "tourist" spots and visited a few places off the beaten path but this time I want to go to as many non-touristy places as possible. Bars, restaurants, stores, whatever, I'm open to any and all suggestions :-D