My PC freezes and screeches.

I am just about done with PCs. I'm at my wit's end. In October I built a gaming PC, and the past 3 or 4 months I've been having this freezing problem. It happens quicker and more often with games. I dusted everything out and tightened what I could on all the wires, I reinstalled Windows and that seemed to help for a bit, but it just did it again. It can't be software if I did a reinstall (I think) but I have no idea what it might be hardware wise. Any help at all would be amazing.