Web Apps vs Native Apps

On the desktop, I prefer using Gmail Offline, Google Keep, Pixlr Editor, LastPass, Google Music, Google Calendar, etc all via Chrome rather than using several individual desktop applications.

If it wasn't for Steam, VLC, Picasa, Google Music Manager, Aperture, Handbrake, Kid3 id3 tag editor, Transmissions, and Automator - Chrome OS would serve me perfectly.

What about you guys; What native apps do you need? Is it possible for you to go Chrome OS only.