In the 25 years since The Simpsons premiered, over 300 actors have appeared as themselves on the show (it's reportedly 644 in total if you're talking about guest actors). Showing up in Springfield has become almost as common to actors' resumes as appearing on Law & Order. While this list can certainly go on for much longer, here are 14 of our favorite celebrity guest appearances on The Simpsons.
Musically inclined? Billboard has put together a complete list of every musical guest to ever appear on The Simpsons. And don't forget The Verge community is currently in the process of reviewing every single Simpsons episode throughout the FXX marathon.


David Crosby - Appeared as himself in "Marge in Chains" (Season 4, Episode 21) and "Homer's Barbershop Quartet" (Season 5, Episode 1)


Anderson Cooper - Appeared as himself in "The Kid is Alright" (Season 25, Episode 6)


The Oscar Selfie - This image never appeared in a Simpsons episode. Creator Matt Groening posted it to Twitter after the infamous selfie was taken at last year's Academy Awards.


Betty White - Appeared as herself in "Missionary: Impossible" (Season 11, Episode 15) and "Homerazzi" (Season 18, Episode 16)


Seth Rogen - Appeared as himself in "Steal This Episode" (Season 25, Episode 9). Rogen also co-wrote and voice acted in "Homer the Whopper" (Season 21, Episode 1)


Janet Reno - Appeared as herself in "Dark Knight Court" (Season 24, Episode 16)


Stephen Hawking - Appeared as himself in "They Saved Lisa's Brain" (Season 10, Episode 22), "Don't Fear the Roofer" (Season 16, Episode 16), "Stop or My Dog Will Shoot!" (Season 18, Episode 20), and "Elementary School Musical" (Season 22, Episode 1)


Conan O'Brien - Appeared as himself in "Bart Gets Famous" (Season 5, Episode 12). O'Brien also wrote the critically acclaimed episode "Marge vs. the Monorail" (Season 4, Episode 12)


James Brown - Appeared as himself in "Bart's Inner Child" (Season 5, Episode 7)


Lucy Lawless - Appeared as herself in "Treehouse of Horrors X" (Season 11, Episode 4)


Larry King - Appeared as himself in "One Fish, Two Fish, Blowfish, Blue Fish" (Season 2, Episode 11) and "Sideshow Bob Roberts" (Season 6, Episode 5)


Leonard Nimoy - Appeared as himself in "Marge vs. the Monorail" (Season 4, Episode 12) and "The Springfield Files" (Season 8, Episode 10). Nimoy's was also a frequent guest on Groening's Futurama.


Stan Lee - Appeared as himself in "I Am Furious Yellow" (Season 13, Episode 18) and "Married to the Blob" (Season 25, Episode 10)


Mark Zuckerberg - Appeared as himself in "Loan-a Lisa" (Season 22, Episode 2)