SpaceX launched its third crew of astronauts to the International Space Station early Friday morning, reusing a Crew Dragon space capsule to fly humans for the first time. The mission, dubbed Crew-2, is the latest flight under NASA’s Commercial Crew Program and will add four more astronauts to the orbital space station.

A used Falcon 9 rocket, last flown for SpaceX’s Crew-1 mission last year, lifted off at 5:49AM ET from Cape Canaveral, Florida carrying Endeavour, the same Crew Dragon capsule that first launched SpaceX’s debut astronaut mission nearly one year ago. For this flight, the Endeavour capsule carried four astronauts from three different countries — SpaceX’s most diverse NASA-managed crew yet.

“Off the Earth, for the Earth, Endeavour is ready to go,” NASA astronaut Shane Kimbrough, the mission’s spacecraft commander, told SpaceX mission control in Hawthorne, California minutes before lifting off.

Kimbrough and fellow NASA astronaut Megan McArthur, serving as the pilot, accompanied mission specialists Akihiko Hoshide of the Japan Aerospace Exploration Agency (JAXA) and Thomas Pesquet, a French aerospace engineer from the European Space Agency (ESA). The crew will spend nearly 24 hours in transit as Endeavour autonomously raises its orbit toward the ISS ahead of a 5:10AM ET docking tomorrow, April 24th.

Sunlight beamed into the windows of Crew Dragon Endeavour as it separated from its Falcon 9 second stage booster roughly 12 minutes after the pre-dawn liftoff, prompting cheers and applause from engineers on a live video feed in SpaceX’s mission control. “Thanks for flying our first flight-proven, crewed Falcon 9,” mission control said to the Endeavour crew, confirming a successful arrival in orbit.

“We’re great, glad to be back in space for all of us, and we’ll send our regards to Crew-1 when we get there,” Kimbrough, seen on live camera feeds from inside Crew Dragon, replied from Endeavour. A stuffed penguin toy, serving as a microgravity indicator, rose from under the astronauts’ seats once they reached orbit. The capsule’s separation occurred just after Falcon 9’s first stage booster returned back to Earth to land on SpaceX’s “Of Course I Still Love You” drone-ship in the Atlantic Ocean.

“We had an incredible launch,” Kimbrough said from Crew Dragon, as the spacecraft orbited Earth over South Africa. “That was pretty special to see the sunlight coming in shortly after liftoff.” McArthur said “the ride was really smooth … We couldn’t have asked for anything better. There may have been some hootin’ and gigglin’ up here” during ascent, she added.

When Crew Dragon was inserted in its orbit, Kimbrough said the crew rushed to look out of the capsule’s windows to see the Falcon 9 second stage “pretty much flying in formation with us” after separating.

Kimbrough, McArthur, Hoshide, and Pesquet will spend six months in space and join seven astronauts already aboard the space station, an orbital science laboratory flying more than 17,000 miles per hour in orbit roughly 250 miles above Earth. On April 28th, a few days after this crew’s arrival, four other astronauts from SpaceX’s Crew-1 mission, which launched to the ISS on November 15th, 2020, will board a separate Crew Dragon capsule and return to Earth to cap their own six-month stay.

Crew-2 marks SpaceX’s third astronaut mission under NASA’s Commercial Crew Program, the agency’s public-private initiative to revive its human spaceflight capabilities after a nearly 10-year dependence on Russian rockets. It’s the second of six operational missions SpaceX is contracted to fly under that program, which awarded the company $2.6 billion in 2014 to develop and fly Crew Dragon. SpaceX’s first crewed mission in May 2020, carrying Bob Behnken and Doug Hurley, counted as a test flight.

The Crew-2 mission marked another reusability milestone for SpaceX, which has launched and reused dozens of Falcon 9 rockets and uncrewed Dragon capsules in the past. This mission was the first to reuse a Falcon 9 rocket and Crew Dragon capsule for flying humans, a capability NASA approved as a modification to SpaceX’s contract last year. That spares SpaceX and NASA the time and money that otherwise would’ve been spent building new capsules for each mission.

The Endeavour capsule went through light refurbishment at SpaceX’s facilities in Cape Canaveral — nicknamed “Dragonland” — after splashing down in the Gulf of Mexico last year with Hurley and Behnken inside. Most of the hardware on the capsule remained, but its thermal shielding, parachutes, and some internal fuel valves were swapped for new ones.

Accompanied by two Russian cosmonauts and NASA’s Mark Vande Hei, who all launched on a Russian Soyuz rocket on April 9th, Crew-2’s stay aboard the ISS will make for a seven-person crew in space for the next several months. During their stay, the crew will conduct an array of microgravity science experiments. The Crew-2 astronauts’ science efforts will center on a cassette-sized device containing human cells to study how those cells respond to various drugs and health conditions in microgravity.

The increased crew size means other science experiments, including a few projects tracking how plants grow and behave in space, will also see some progress. “It’s like a party up there,” said Annmarie Eldering, a project scientist at NASA’s Jet Propulsion Laboratory working on Orbiting Carbon Observatory-3, a device astronauts will use to measure carbon dioxide in Earth’s atmosphere. “When you get all those measurements from space, in the same time, same place, it’s really powerful for science,” Eldering said Friday morning in a live NASA broadcast.

Update April 23rd, 11:24AM ET: This story was updated to add quotes and details from the astronauts after launch.